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1992). Measurement of total plasma and CSF homocysteine by fluorescence detection followed HPLC and pre-column derivatization with OPA, /. Chromatogr. 579, 55-62. , et al. (1992). Treatment of Alzheimer-type dementia with intravenous cobalamin, Clin. Therapeutics 14, 426-437. Jancovic, J. (2002). Levadopa strengths and weaknesses, Neurology 58, S19-S32. , Tanaka, M , Muramatsu, M , et al. (1994). Determination of nitrite by HPLC with EC: Measurement of nitric oxide synthase activity in rat cerebellum cytosol, J.

18, 925-964. Hughes, A. J. D. , Kilford, L. and Lees, A. J. (1992). Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases, J. Neurol. Neurosurg. Psychiatry 55, 181-185. Hunot, S. and Hirsch, E. C. (2003). Neuroinflammatory processes in Parkinson's disease, Ann. Neurol 53 (Suppl. 3), S49-S60. Cobalamin deficiency and its dynamic impact on neurotoxicity and oxidative stress 41 Hyland, K. and Bottiglieri, T. (1992). Measurement of total plasma and CSF homocysteine by fluorescence detection followed HPLC and pre-column derivatization with OPA, /.

A. Qureshi et al. Figure 2. CSF levels of homocysteine in PD patients (On and Off groups) and healthy controls. All the values are expressed as mean ± SEM. ***/? 001. 001) in PD patients. In On and Off groups, respectively. Figure 3 shows the relationship between CSF homocysteine and nitrite levels in Controls and patients in both On and Off groups. DISCUSSION Tremor, akinesia, rigidity and postual instability are key signs of Parkinson's disease. The most important one is akinesia, which includes decreased spontaneous locomotor activity, slowness of movement, awkwardness and freezing.

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