By Bradley K. Taylor, David P. Finn

Pain is the commonest cause humans search clinical support. The remedy of persistent ache is a big unmet medical want and its impression on healthiness, health and wellbeing, society and the economic climate is significant. ache is an integrative, whole-systems (patho)physiological phenomenon and behavioural neuroscience performs a key function in advancing our realizing of discomfort. This quantity brings jointly a chain of authoritative chapters written by means of top specialists in preclinical and medical elements of soreness neurobiology. Behavioural techniques to the research of continual or power discomfort in animal types or people are on the center of the quantity, however the anatomical, physiological, neurochemical and molecular mechanisms that underpin behavioural adjustments also are emphasised. ​

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Extra resources for Behavioral Neurobiology of Chronic Pain

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M. Bischoff Scheef L, Jankowski J, Daamen M, Weyer G, Klingenberg M, Renner J et al (2012) An fMRI study on the acute effects of exercise on pain processing in trained athletes. Pain 153(8):1702–1714 Scholz J, Woolf CJ (2007) The neuropathic pain triad: neurons, immune cells and glia. Nat Neurosci 10(11):1361–1368 Schreiber KL, Martel MO, Shnol H, Shaffer JR, Greco C, Viray N et al (2013) Persistent pain in postmastectomy patients: comparison of psychophysical, medical, surgical, and psychosocial characteristics between patients with and without pain.

Brain Res 2(1363):72–80 O’Brien T, Breivik H (2012) The impact of chronic pain–European patients’ perspective over 12 months. Scand J Pain 3:23–29 Olesen SS, Brock C, Krarup AL, Funch-Jensen P, Arendt-Nielsen L, Wilder-Smith OH et al (2010) Descending inhibitory pain modulation is impaired in patients with chronic pancreatitis. Clin Gastroenterol Hepatol 8(8):724–730 Persistent Postsurgical Pain 27 Parker PA, Youssef A, Walker S, Basen-Engquist K, Cohen L, Gritz ER et al (2007) Short-term and long-term psychosocial adjustment and quality of life in women undergoing different surgical procedures for breast cancer.

Berge 3 Symptoms, Signs, and Readouts Research in behavioral pharmacology is often motivated by human disease. A thorough description of pain in man is beyond the scope of this chapter, but some points are worth mentioning. Clinically, acute pain is usually studied in the context of surgery. Postsurgical pain is characterized by ongoing pain exacerbated by movements (Brennan 2011). Pressure pain thresholds are reduced around the wound and inversely correlate with spontaneous pain and pain during movement (Møiniche et al.

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