By Robert M. Berne MD, Bruce A. Stanton PhD

Lengthy revered for its scientifically rigorous procedure, this best-selling textual content now contains significant updates to carry you the entire newest wisdom within the box. Honed and shortened to stress the middle info wanted by means of scholars of body structure this day, it additionally contains a new full-color layout and all-new full-color art to augment clarity and enhance your comprehension of each proposal. With entry to the entire contents on-line at scholar seek advice, this standard e-book grants an in-depth realizing of body structure extra powerfully and successfully than ever before.

  • An organ system-based process truly describes all the mechanisms that keep watch over and keep an eye on physically function.
  • Key experimental observations and examples supply a wealthy realizing of the body's dynamic processes.
  • Student seek advice entry enables you to view the whole contents of the e-book on-line, anyplace you pass, practice speedy searches, faucet into appropriate bonus content material from different scholar seek advice titles, try out your figuring out with USMLE-style evaluation questions, upload your individual notes and bookmarks, and masses more.
  • Updated insurance all through is helping extend your realizing of the most up-tp-date traits in body structure and medication, together with the most recent mobile and molecular wisdom.
  • Shaded containers spotlight and clarify very important medical and molecular information.
  • New part editors make sure that you're getting the most up to date, such a lot clinically proper info to be had at the present time.
  • Key issues sections pinpoint the main need-to-know details in every one chapter.

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CONCEPT OF STEADY-STATE BALANCE The concept of steady-state balance can be illustrated by considering a river on which a dam is built to create an artificial lake. Each day, water enters the lake from the various streams and rivers that feed it. In addition, water is added by rain and snow. At the same time, water is lost through the spillways of the dam and by the process of evaporation. , steady-state balance), the rate at which water is added, regardless of the source, must be exactly matched by the amount of water lost, again by whichever route.

In the kidney, the proximal tubule reabsorbs the glucose that was filtered at the glomerulus and thereby prevents it from being lost in urine. Uptake of glucose into the epithelial cell from the lumen of the small intestine and from the lumen of the proximal tubule is a secondary active process involving the Na+-glucose symporters SGLT1 and SGLT2. SGLT2 transports 1 glucose molecule with 1 Na+ ion, and the energy in the electrochemical gradient for Na+ (into the cell) is used to drive the secondary active uptake of glucose.

Normally, cholesterol is ingested in the diet and transported via blood in association with lipoproteins. Low-density lipoproteins (LDLs) in blood carry cholesterol to cells, where they bind to LDL receptors on the surface. Once the receptors bind LDL, they collect into "coated pits" and are endocytosed as clathrin-coated vesicles. The endo-some that is formed by the process removes the LDL and recycles the receptor back to the cell surface. The LDL is then degraded in lysosomes and the cholesterol made available to the cell.

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