By Werner Risau (auth.), Pierre-Olivier Couraud, Daniel Scherman (eds.)
The endothelial cells of the cerebral vasculature represent, including perivascular parts (astrocytes, pcricytes, basement membrane), the blood-brain barrier (BBB), which strictly limits and in particular controls the exchanges among the blood and the cerebral extracellular spacc.The life of one of these actual, enzymatic, and energetic barrier separating the principal apprehensive approach has extensive physiological, organic, pharmacological, and patho logical results, such a lot of which aren't but absolutely elucidated. The Cerebral Vascular Biology convention (CVB '95) was once equipped and held on the "Carre des Sciences" in Paris on July I 0-12, 1995. just like the CVB '92 convention held in Duluth, Minnesota, 3 years in the past, the goals have been to supply a discussion board for presentation of the latest progresses and to stimulate discussions within the ticld of the biology, body structure. and pathology of the blood-brain barrier. The Paris convention accumulated greater than !50 individuals. together with investigators in simple neuroscience, physicians. and stu dents, who actively contributed to the medical application via their oral or poster shows. This quantity features a number of brief articles that summarize lots of the new facts that have been offered on the convention. Six thematic components specialize in physiological transports. drug supply, multidrug resistance P-glycoprotein, sign transduction on the BBB. interactions among the immune approach and the cerebral endothelial cells, and the blood-brain barrier-related pathologies within the critical anxious method. additionally, introductory articles current new insights within the swiftly evolving issues of cerebral angiogenesis and gene move to the brain.
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Additional info for Biology and Physiology of the Blood-Brain Barrier: Transport, Cellular Interactions, and Brain Pathologies
2. Chung S. , Giacomini K. , and Brett C. , Biochim. Biophys. Acta 1193: I 0-16. 3. Huxtable R. , Prog. Neurobiol. 32:471-533. 4. Keep R. F. ,J. Neurochem. 5. Keep R. , and Betz A. • Am. J. Physiol. 267:Cl616-Cl622. 6. , Nagelhus E. , and Ottersen 0. , 1991, Elevation of taurine in hippocampal extracellular fluid and cerebrospinal fluid of acutely hypoosmotic rats: contribution of influx from blood?. J. Neurochem. 56:690-697. 7. , Pettigrew K. , and Rapoport S. , 1978, Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat, Am J Physio/235:H299-H307.
9 THE BLOOD-BRAIN BARRIER, POTASSIUM, AND BRAIN GROWTH Richard F. Keep, 1 Jianming Xiang, 1 and A. 2 1 2 Department of Surgery (Neurosurgery) Departments of Pediatrics and Neurology University of Michigan Ann Arbor, Michigan 48105-0532 SUMMARY Blood-brain barrier (BBB) permeability to small polar molecules, including potassium, is increased early in rat development and this may reflect the need of the growing brain for potassium. The latter was tested by examining the effect of dexamethasone on BBB x6 Rb (potassium) permeability and brain growth.
L'efficacite du transport de Ia 3 H-L-alanine du sang vers le cerveau est egalement tres faible (Vmax < 20 nmol/min/g). L'addition de BCH ( 4nmol/1) pour eliminer Ia contribution du systeme deL-transport ne provoquait pas de baisse significative du transport deL-alanine. Pourtant, Ia presence deL-serine non marquee ( 4 nmol/1) dans le milieu de perfusion a provoque une reduction de la capture de L-alanine (P < 0,05 ). II semble que le systeme deL-transport n'est peut-etre pas essentiel pour le transport de Ia L-alanine a travers Ia BHE, et que la L-serine et la L-alanine se partagent le meme systeme de transport.