By I. Klatzo (auth.), Prof. Dr. Yutaka Inaba, Dr. Igor Klatzo, Dr. Maria Spatz (eds.)

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Acta Neuropathol (Bed) 64: 122-128 7. Ogata J, Hochwald GM, Cravito H, Ransohoff J (1972) Distribution of intraventricular horseradish peroxidase in normal and hydrocephalic cats. J Neuropathol Exp Neurol 31:154-163 8. Simpson I, Rose B, Loewenstein WR (1977) Size limit of molecules permeating the junctional membrane channels. Science 195:294-296 9. Westergaard E, Deurs B, Bronsted HE (1977) Increased vesicular transfer of horseradish peroxidase across cerebral endothelium, evoked by acute hypertension.

Swelling of the astrocytes was followed by extensive fibrillary gliosis of the astrocytes. These observations are consistent with the measurements of water content previously studied, and provide further support for the concept introduced by Klatzo, that loss of water from edematous tissue is closely allied to the dynamics of protein clearance. References 1. Hirano A (1969) The fine structure of brain edema. In: Bourne G (ed) The structure offunction of nervous tissue. Academic, New York, p 69 2.

Naruse S, Holicawa Y, Tanaka C, Hirakawa K, Nishikawa H, Yoshizaki K (1982) Proton nuclear magnetic resonance on brain edema. J Neurosurg 56:747-752 Edema Fluid and Electron Microscopic Studies in 6-ANA Brain Edema 31 17. Sasaki S (1982) Brain edema and gliopathy induced by 6-aminonicotinamide intoxication in the central nervous system of rats. Am J Vet Res 43: 1691-1695 18. Schneider R, Cervos-Navarro J (1974) Acute gliopathy in spinal cord and brain stem induced by 6-aminonicotinamide. Acta Neuropathol (Bed) 27: 11-23 19.

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