By Eugene C. Toy, Margaret O Uthman, Edward Uthman, Earl J. Brown

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Additional info for Case Files: Pathology (Lange Case Files), 2nd edition

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E. 1] A. Hereditary nonpolyposis colorectal carcinoma, also known as Lynch syndrome, presents as an autosomal dominant disorder characterized by the formation of colon cancer, usually early in life. The disorder is associated with the hereditary nonpolyposis colorectal cancer gene and with the formation of multiple colonic polyps, although fewer than seen in the family adenomatous polyposis syndrome. 2] D. The presence of dysplastic epithelium within a colonic polyp defines adenomas of the colon, the three types of which are tubular adenomas, mixed tubulovillous (villoglandular) adenomas, and villous adenomas.

The classification and pathogenesis of acute and chronic gastritis are discussed below. Ulcer: A disruption of the mucosa extending through the muscularis mucosa into the submucosa or deeper. Ulcers may occur anywhere in the gastrointestinal tract but are seen most often in the stomach and duodenum, associated with peptic ulcer disease. Peptic ulcer disease: Peptic ulcers are chronic, usually solitary lesions of the gastrointestinal mucosa caused by the action of acid-peptic juices. Both acid and pepsin are necessary for peptic ulcer disease to develop.

Workup finds his serum gastrin levels to be markedly elevated, and an abdominal CT scan finds a large mass in the tail of the pancreas. A biopsy from this pancreatic mass finds an islet-cell adenoma that secretes gastrin. Which of the following is the best diagnosis? A. B. C. D. E. 3] CASE FILES: PATHOLOGY A 55-year-old woman seeks medical attention for fatigue and malaise that have been worsening over the last 2 months. She also has noticed loss of appetite and early satiety. Evaluation reveals an ulcerative mass located along the lesser curvature, and a biopsy shows an infiltrating adenocarcinoma.

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