By Nicole M. Le Douarin (auth.), Ira B. Black (eds.)

A vital challenge in neurobiology matters mechanisms that generate the professional­ came across range and specificity of the worried approach. what's the substance of diversification and specificity on the molecular, mobile, and platforms degrees? four How, for instance, do 1011 neurons each one shape nearly 10 interconnec­ tions, permitting basic physiological functionality? How does disruption of those strategies lead to human sickness? those court cases characterize the efforts of molecular biologists, embryologists, neurobiologists, and clinicians to process those matters. during this quantity are grouped via topic to give the forms The chapters of equipment used to method every one person quarter. part I offers with embry­ ogenesis and morphogenesis of the anxious method. In bankruptcy three, Weston and colleagues describe using monoclonal antibodies that realize particular neuronal epitopes (including particular gangliosides) for the aim of defining heterogeneity within the neural crest, an enormous version procedure. Immunocyto­ chemical research unearths the life of targeted sUbpopulations in the crest at super early levels; cells show neuronal or glial binding styles on the time of migration. hence, interactions with the surroundings may well decide on for predetermined populations. Le Douarin reaches related conclusions in bankruptcy 1 via reading migratory pathways and developmental potentials in crest of quail-

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The dorsoventral pathway between somite and neural tube then becomes available, and cell migration can take place ventrally. This coincides with the dissociation of the somite into dermomyotome and sclerotome. The lateromedial expansion of sclerotomal cells, which will surround the axial organs (notochord and neural tube) to form the vertebrae, prevents the crest cells from reaching the paranotochordal region. As a result, they accumulate between the neural tube and the somitic mesenchyme and form the DRGs (Fig.

C) Cone-shaped termination (endfeet) of radial glial fibers at the pial surface of the fetal cerebral wall. phenotype can be verified by other morphological criteria, demonstrated that only cells that belong to the astrocytic class are immunoreactive and that no neuronal elements contain reaction product within their cytoplasm. The specificity of the antibodies directed against GFAP is particularly explicit in areas where radial glial fibers are apposed to the somata of neurons that are identified by counterstaining with the Nissl method.

Sequential observation of the chimeras 12-48 hr after grafting showed that the pattern of disaggregation of the implanted tissue was not exactly the same for all kinds of ganglia. , 1980). During the migration process and after settling in their definitive position, most of the grafted cells underwent intense proliferation (Dupin, 1982; Dupin and Le Douarin, in preperation). From 6 days onward, the definitive localization of the implanted cells was established for all types of grafts. 1 . Graft of Autonomic Ganglia Grafted sympathetic ganglia did not contribute to the enteric plexuses, whereas ciliary-ganglion cells migrated into the ganglion of Remak and into Auerbach's and Meissner's plexuses of the mid- and hindgut.

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